Successful Treatment of Refractory Post-Transplant Lymphoproliferative Disorder With Chimeric Antigen Receptor T-Cell Therapy in a Heart Transplant Recipient.

Post-transplant lymphoproliferative disorders (PTLDs) are opportunistic malignancies that complicate the success of hematopoietic stem cell or solid organ transplantation. These disorders often arise post-transplant due to the immunosuppression required for minimizing the risk of rejection of donor tissue. First-line treatment of these disorders includes limiting immunosuppression when permissible. Subsequent treatment includes the use of monoclonal anti-CD20 antibody (rituximab), and/or combination chemotherapy. Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigm in many lymphoid malignancies. It is not approved for PTLD due to exclusion of PTLD patients from pivotal clinical trials. Also, its utilization post-transplant can be complex and multidisciplinary care is of utmost importance for successful administration of a potentially curative treatment. We present a 68-year-old patient with history of heart transplant for non-ischemic cardiomyopathy, diagnosed with PTLD that was refractory to treatment using current guidelines until successfully receiving CAR T-cell therapy.

The Australian Shark-Incident Database for quantifying temporal and spatial patterns of shark-human conflict.

We describe the Australian Shark-Incident Database, formerly known as the Australian Shark-Attack File, which contains comprehensive reports of 1,196 shark bites that have occurred in Australia over 231 years (1791-2022). Data were collated by the Taronga Conservation Society Australia using purpose-designed questionnaires provided to shark-bite victims or witnesses, media reports, and information provided by the department responsible for fisheries in each Australian state (including the Northern Territory). The dataset includes provoked and unprovoked bites from fresh, brackish, and marine waters in Australia. Data span 22 suspected shark species. This dataset will be publicly available, and can be used by analysts to decipher environmental, biological, and social patterns of shark bites in Australia. The information will aid scientists, conservationists, authorities, and members of the public to make informed decisions when implementing or selecting mitigation measures.